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KMID : 0367419760170100029
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Journal of Korean Pediatric Society
1976 Volume.17 No. 10 p.29 ~ p.33
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On the Permeability of INH through Blood-Brain Barrier
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金仲植/Kim, Joong Sik
洪永杓/Hong, Young Pyo
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Abstract
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Serum and cerebrospinal fluid INTH levels were studied in tuberculous and non tuberculous meningitis cases following oral administration of INH 4 mg. per kg. of body weight. The measurements were done by the biological method. The INH levels 1 hour after administration were about half-of serum in prolonged convulsion and tuberculous meningitis cases. Two hours after administration, the cerebrospinal fluid levels in normal children showed only one third ofsurum. Whereas in meningitis and prolonged convulsion cases, the INH levels in cerebrospinal fluid were same concentration as serum.
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